THE PKRRATING DIARIES

3B). R526 within the loop in between αJ and αI anchors the C-terminal percentage of the activation loop by forming a salt bridge with E458 at the base of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the key chain carbonyl of R413. The idea of your activation section is stabilized by a hydrogen bond amongst Y454 and E480 from αfile.